ABSTRACT
To evaluate the impact of luteal phase support with vaginal progesterone on pregnancy rates in the intrauterine insemination [IUI] cycles, stimulated with clomiphene citrate and human menopausal gonadotropin [hMG], in sub fertile couples. This prospective, randomized, double blind study was performed in a tertiary infertility center from March 2011 to January 2012. It consisted of 253 sub fertile couples undergoing ovarian stimulation for IUI cycles. They underwent ovarian stimulation with clomiphene citrate [100 mg] and hMG [75 IU] in preparation for the IUI cycle. Study group [n = 127] received luteal phase support in the form of vaginal progesterone [400 mg twice a day], and control group [n = 126] received placebo. Clinical pregnancy and abortion rates were assessed and compared between the two groups. The clinical pregnancy rate was not significantly higher for supported cycles than that for the unsupported ones [15.75% vs. 12.69%, p = 0.3]. The abortion rate in the patients with progesterone luteal support compared to placebo group was not statistically different [10% vs. 18.75%, p = 0.45]. It seems that luteal phase support with vaginal progesterone was not enhanced the success of IUI cycles outcomes, when clomiphene citrate and hMG were used for ovulation stimulation
ABSTRACT
The aim of our study was to investigate the effect of coping strategies, personality trait and social support as the main social and psychological factors on infertility stress. This study was conducted on 201 infertile Iranian women referred to the Vali-e-Asr Reproductive health Research Center, and completed the following questionnaires: The fertility problem inventory, measuring perceived infertility related stress [Newton CR, 1999], big five factor personality questionnaire [Farahani, 2009], multidimensional scale of perceived social support MSPS [Zimmet 1988], and multidimensional assessment of coping [Endler, 1990].The results were then analyzed using the Pearson Correlation and stepwise regression. Infertility stress has negative and significant relation with emotion-oriented coping method, perceived social support and bring extrovert. It has a positive, significant relation with emotion-oriented coping method, obsessive compulsive disorder [OCD]. The results of the stepwise regression showed that emotion-oriented coping method, OCD and being extrovert are suitable predictors of infertility stress. About 22% of the infertility stress variance was explained by coping strategies and personality trait. Therefore our result demonstrates the importance of social and psychological factors on experiencing the infertility stress